Hematopoietic stem cell regulation. I. Acute effects of hypoxic-hypoxia on CFU kinetics.

Hematopoietic stem cell regulation. II. Chronic effects of hypoxic-hypoxia on CFU kinetics.

Hematopoietic Stem Cell Regulation. I. Acute Effects of HypoxicuHypoxia on CFU Kinetics

This paper, the first of a series on the regulation of the hematopoIetic stem cell, examines the effects of stem cell kinetics during an acute exposure to hypoxichypoxia. This physiologic perturbation was chosen because of the well-established role It plays In Influencing erythropoiesis. BDF, male mice were exposed to a simulated altitude of 22,000 ft for periods of time ranging from 3 to 48 hr...

تأثیر غلظت 1% اکسیژن بر بیان ژن Conexin 43 در سلولهای بنیادی مزانشیمی مشتق از مغز استخوان موش (C57(BL/6

Introduction: Oxygen tension is one of the most important stimuli in stem cell biology. In this study, we investigate the considerable influence of hypoxia on CX43 gene expression as one of the most important gap junction on the surface of mesenchymal stem cells. Methods: Mesenchymal stem cells were isolated from C57BL/6 mouse bone marrow and cultured in DMEM medium under low oxygen tension (...

Effect of daunorubicin drug with and without cimetidine on the nucleated cells of bone marrow of balb/c mouse

Introduction: Hematopoiesis is an on going process mammalian marrow system. A few cells from the nucleated cells of bone marrow are hematopoietic cells which include primary stem cells, precursor cells and progenitor cells. Primary stem cells and progenitor cells are able to produce colonies in culture medium (CFU-C) and irradiated mouse spleen (CFU-S). A hematopoietic cell is alive and act...

HY POXIA AND I TS INFLUEN CES ON THE CARDIOVASCULAR AND RESPIRATORY SYSTEMS OF SPONTANEOUSLY BREATHING CATS

Effects of acute systemic hypoxia on the cardiovascular system (CYS) and respiration of spontaneously breathing cats were studied in two conditions. 1): Hypoxic air (6-8% 02 in N2) was given to the animal to induce systemic hypoxia for 20 minutes. Hyperventilation at this condition lowered arterial C02 tension (PaC02 hypocapnia). 2): In the second run, induction of hypocapnia was prevented ...